The regulation of cellular iron metabolism

This review is an overview of cellular iron metabolism and regulation, describing the function of key proteins involved in these processes, with particular emphasis on the liver''s role in iron homeostasis, as it is the main target of iron deposition in pathological iron overload. Current knowledge on their roles in maintaining iron homeostasis ...

Regulation of iron transport and the role of transferrin

Background: Iron is utilized by several proteins as cofactor for major biological processes. However, iron may also harm cells by catalyzing the generation of free radicals and promoting oxidative stress. Acquisition, transport, utilization and storage of iron are tightly controlled to meet physiological needs and prevent excessive accumulation of the metal within cells.

The unique regulation of iron-sulfur cluster biogenesis in a …

2014520 · Iron-sulfur (Fe/S) proteins play crucial roles for the functioning of both prokaryotic and eukaryotic cells, being required for biological functions ranging from electron …

Regulation of tissue iron homeostasis: the macrophage …

2020130 · Here, we summarize the significance of tissue-specific regulation of iron availability and highlight how resident macrophages are critical for this process. This tissue-dependent regulation has broad implications for understanding both resident macrophage function and tissue iron homeostasis in health and disease.

The unique regulation of Aedes aegypti larval cell ferritin …

200751 · Volume 37, Issue 5, May 2007, Pages 418-429. The unique regulation of Aedes aegypti larval cell ferritin by ironAedes aegypti larval cell ferritin by iron

The unique regulation of iron-sulfur cluster biogenesis in a …

Iron-sulfur clusters function as cofactors of a wide range of proteins, with diverse molecular roles in both prokaryotic and eukaryotic cells. Dedicated machineries assemble the clusters and deliver them to the final acceptor molecules in a tightly regulated process. In the prototypical Gram-negative bacterium Escherichia coli, the two existing iron-sulfur cluster assembly systems, iron …

The regulation of iron transport

20131017 · The regulation of iron export is controlled predominantly at the systemic level by the master regulator of iron homeostasis hepcidin. Hepcidin, in turn, responds to changes in body iron demand, making use of a range of regulatory mechanisms that center on the bone morphogenetic protein signaling pathway. This review provides an overview of ...

Mechanistic and regulatory aspects of intestinal iron …

2014815 · Regulation of iron homeostasis in enterocytes goes beyond the FPN1-HEPC axis, involving specific physiological adaptations that have evolved to maximize iron extraction from the diet when the demand for iron increases. ... Among essential dietary nutrients, the homeostasis of iron is unique given that free iron is highly reactive and no active ...

New regulators of systemic iron homeostasis | Signal

2021721 · Metrics. In a recent study published in Blood, Jiang et al. 1 describe two new mechanisms that may contribute to systemic iron homeostasis. They first identify the methylcytosine dioxygenase Tet1 ...

Coordinated regulation of iron metabolism in

2021324 · A GATA-type transcription factor that regulates iron homeostasis in fungi was first identified in the maize pathogen Ustilago maydis.The gene encoding the transcription factor, urbs1, was identified following chemical mutagenesis and screening for mutants defective in the regulation of siderophore biosynthesis (Voisard et al. 1993) aracterization of the urbs1 …

Regulation of iron homeostasis by the p53-ISCU pathway

20151112 · Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. p53 activation induced ISCU expression through binding to an intronic p53-binding site.

Iron Metabolism

202285 · Iron Excretion. Firstly, it is important to note that the human body has no specific mechanism for iron excretion, and therefore regulating iron absorption to match the natural losses, is a crucial part of iron metabolism.. Approximately 1-2mg of iron are lost from the body each day from the skin and gastrointestinal mucosa.A well-balanced diet contains sufficient iron to …

The unique regulation of Aedes aegypti larval cell ferritin …

The unique regulation of Aedes aegypti larval cell ferritin by iron. Geiser DL(1), Mayo JJ, Winzerling JJ. Author information: (1)Department of Nutritional Science, College of Agriculture and Life Sciences and Center for Insect Science, University of Arizona, 1177 East 4th Street, Shantz Building, Room 405, Tucson, AZ 85721-0038, USA. dlgeiser ...

The unique regulation of iron-sulfur cluster biogenesis in a …

2014520 · Therefore, T. potens has a unique organization and regulation of Fe/S cluster assembly genes, among Gram-positive bacteria. Overall Structure of T. potens IscR. Apo-IscR …

Regulation of Iron Homeostasis and Related Diseases

202052 · The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway and regulates the iron intake from food and erythrocyte recovery into the bloodstream by secreting hepcidin. Under iron deficiency, hypoxia, and hemorrhage, the …

Regulation of iron balance

A tight regulation of iron balance is essential to avoid both iron deficiency and overload. The regulation of iron metabolism involves the interaction of a number of specific proteins as well as the interplay between iron absorption, recycling, and iron loss. This topic review will discuss these factors [ 1 ]. Clinical implications are ...

The unique regulation of Aedes aegypti larval cell ferritin …

The unique regulation of Aedes aegypti larval cell ferritin by iron. @article{Geiser2007TheUR, title={The unique regulation of Aedes aegypti larval cell ferritin by iron.}, author={Dawn L …

Regulation of iron transport and the role of transferrin

However, iron may also harm cells by catalyzing the generation of free radicals and promoting oxidative stress. Acquisition, transport, utilization and storage of iron are tightly controlled to meet physiological needs and prevent excessive accumulation of the metal within cells.

The unique regulation of iron-sulfur cluster biogenesis in a …

2014428 · A major role of IscR in R. sphaeroides iron-dependent regulation was suggested in a bioinformatic study (Rodionov et al., PLoS Comput Biol 2:e163, 2006), which predicted a binding site in the ...

The Regulation of Iron Absorption and Homeostasis

The regulation of iron homeostasis by inflammatory stimuli is important in the innate immune response to infections and cancers. Increasing hepcidin levels during infection has the effect …

Regulation of iron balance

20211123 · A tight regulation of iron balance is essential to avoid both iron deficiency and overload. The regulation of iron metabolism involves the interaction of a number of specific proteins as well as the interplay between iron absorption, recycling, and iron loss. This topic review will discuss these factors [ 1 ].

Cellular Iron Metabolism and Regulation

Abstract. Iron is an essential trace element in the human body, but excess iron is toxic as it contributes to oxidative damage. To keep iron concentration within the optimal physiologic range, iron metabolism at the cellular level and the whole systemic level are tightly regulated. Balance of iron homeostasis depends on the expression levels ...

The Regulation of Iron Absorption and Homeostasis

Hepcidin is a negative regulator of iron absorption and recycling, achieving this by binding to the only known cellular iron exporter ferroportin and causing its internalisation and degradation, thereby reducing iron efflux from target cells and reducing serum iron levels.

Tissue-Specific Regulation of Iron Metabolism and Heme …

199711 · However, to fully comprehend the peculiar regulation of iron metabolism in erythroid cells, its unique aspects will be compared with those encountered in other tissues. With this background and relevant discussion of heme pathway enzymes, it should become obvious that while in nonerythroid cells heme-synthesis rate depends on the rate of ALA ...

Regulation of iron metabolism by hepcidin

Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores. Hepc … Regulation of iron metabolism by hepcidin Annu Rev Nutr. 2006;26:323-42. doi: 10.1146/annurev.nutr.26.061505.111303. Authors Elizabeta ...

Mechanisms and Regulation of Intestinal Iron Transport

201811 · Iron is necessary for several critical physiological functions, including oxygen transport, regulation of cell growth and differentiation, energy production, and control of gene expression. Mammals have developed sophisticated regulatory mechanisms that govern iron absorption, storage, and recycling.

The unique regulation of Aedes aegypti larval cell ferritin …

The blood meal provides a high level of iron that is required for egg development. We are interested in developing control strategies that interfere with this process. We report the temporal effects of iron exposure on iron metabolism of Aedes aegypti larval cells. ... Dive into the research topics of ''The unique regulation of Aedes aegypti ...

The unique regulation of Aedes aegypti larval cell ferritin …

The unique regulation of Aedes aegypti larval cell ferritin by iron. @article{Geiser2007TheUR, title={The unique regulation of Aedes aegypti larval cell ferritin by iron.}, author={Dawn L Geiser and Jonathan J. Mayo and Joy Winzerling}, journal={Insect biochemistry and molecular biology}, year={2007}, volume={37 5}, pages={ 418-29 } }

The Regulation of Iron Absorption and Homeostasis

The regulation of iron homeostasis by inflammatory stimuli is important in the innate immune response to infections and cancers. Increasing hepcidin levels during infection has the effect of sequestering iron in tissues and reducing serum iron levels, effectively withholding iron from invading pathogens. Over prolonged periods of time, such as ...

The unique regulation of Aedes aegypti larval cell ferritin …

200761 · Request PDF | The unique regulation of Aedes aegypti larval cell ferritin by iron | Mosquitoes must blood feed in order to complete their life cycle. The blood meal provides a …

Cellular Iron Metabolism and Regulation | SpringerLink

2019828 · 2.2 Regulation of Iron Metabolism. Iron homeostasis in the body is regulated at two different levels, the systemic level and the cellular level [ 8 ]. The systemic iron level is mainly balanced by the controlled absorption of dietary iron by intestinal enterocytes, the cells that line at the interior of the intestines.

Physiology of Iron Metabolism

2014512 · Regulation of iron absorption and exportation by enterocytes. Both heme and non-heme iron are absorbed by specific pathways, including divalent metal transporter-1 (DMT-1) and heme carrier protein (HCP1), in association with the ferrireductase, duodenal cytochrome B (Dcytb). Within the cell, iron can be stored within the ferritin molecule.

The liver in regulation of iron homeostasis

201791 · The liver in regulation of iron homeostasis Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G157-G165. doi: 10.1152/ajpgi.00004.2017. Epub 2017 Jun 8. Authors Gautam Rishi 1, V Nathan Subramaniam 2 Affiliations 1 Liver Disease and Iron Disorders Research Group, Institute ...

Regulation of Iron Homeostasis and Related …

2020226 · The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway and regulates the iron intake from food and erythrocyte recovery into the …

Regulation of iron homeostasis by the p53-ISCU …

20151112 · Regulation of iron homeostasis by p53. ( a) Western blot analyses of FTH1 and TFRC in HCT116 p53−/− or HCT116 p53+/+ cells harvested at the indicated times after ADR treatment (2 μg/ml for 2 ...

The unique regulation of iron-sulfur cluster biogenesis in a …

201463 · Rrf2-like regulator; transcription regulation; helix-turn-helix motif; DNA recognition; specificity modulation; Iron-sulfur (Fe/S) proteins play crucial roles for the …

Regulation of tissue iron homeostasis: the macrophage …

2020130 · Indeed, iron is now thought to be spatially regulated in various tissues on a microenvironmental scale and in a time-dependent manner — such as during wound repair ( 60 – 63 ), wherein resident M2-like Mɸs are largely responsible for the fine-tuned iron uptake and release necessary for proper restoration.

On Iron Metabolism and Its Regulation

2021427 · Figure 2. Cellular iron regulation. The intracellular iron pool is regulated by the binding of IRP1 and IRP2 to IRE. IRP1 and IRP2 are RNA binding proteins that interact with IRE to control the translation of proteins involved in iron metabolism. IRPs are either present at the 3′ UTR or the 5′ UTR of the target mRNA.

The liver in regulation of iron homeostasis

201791 · Apart from being the storage site for excess body iron, it also plays a vital role in regulating the amount of iron released into the blood by enterocytes and macrophages. Since iron is essential for many important physiological and molecular processes, it increases the importance of liver in the proper functioning of the body''s metabolism.

The unique regulation of Aedes aegypti larval cell ferritin …

200751 · Iron ICP-MS is currently the most sensitive measurement of iron concentration with a level of detection in the range of ppb. This technique has been used to determine iron in …

The unique regulation of iron-sulfur cluster biogenesis in a …

The existence of a functional IscR in the unique Gram-positive bacterium Thermincola potens is demonstrated and an unforeseen conservation of the unique mechanism of sequence …

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